Role of caffeine in slowing progression of myopia: 1-year results from a prospective, longitudinal clinical trial.

Purpose: To determine the role of topical caffeine in slowing progression of myopia, both as a standalone treatment and in combination with atropine.

Methods: In a prospective, randomized, dispensing clinical trial, 96 children with myopia, aged 6-13 years, spherical equivalent (SE) from -0.50 diopters (D) to -6.

Super-photostable organic dye for long-term live-cell single-protein imaging.

Organic dyes play a crucial role in live-cell imaging because of their advantageous properties, such as photostability and high brightness. Here we introduce a super-photostable and bright organic dye, Phoenix Fluor 555 (PF555), which exhibits an order-of-magnitude longer photobleaching lifetime than conventional organic dyes without the requirement of any anti-photobleaching additives. PF555 is an asymmetric cyanine structure in which, on one side, the indole in the conventional Cyanine-3 is substituted with 3-oxo-quinoline.

ETV2/ER71 regulates hematovascular lineage generation and vascularization through an H3K9 demethylase, KDM4A.

ETV2/ER71, an ETS (E-twenty six) transcription factor, is critical for hematopoiesis and vascular development. However, research about the molecular mechanisms behind ETV2-mediated gene transcription is limited. Herein, we demonstrate that ETV2 and KDM4A, an H3K9 demethylase, regulate hematopoietic and endothelial genes.

Post-synthesis surface modification of Cu/Zr metal azolate framework: A pathway to highly sensitive electrochemical biosensors for atrazine detection.

Background: Atrazine (ATZ), a pesticide that poses serious health problems, is observed in the environment, thereby prompting its periodic monitoring and control using functional biosensors. However, established methods for ATZ detection have limited applicability. Two-dimensional (2D) metal azolate frameworks (MAF) have a higher surface area per unit volume and provide easier access to active sites.