Publications by authors named "T K Giri"

Introduction Epilepsy is a chronic disorder that requires patient education for management and to avoid triggers and complications. This study aims to evaluate and compare the effectiveness of two artificial intelligence (AI) tools, ChatGPT (version 3.5, OpenAI, Inc.

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Article Synopsis
  • Conventional eye drops have a short residence time in the eye, leading to the need for a more effective delivery system.
  • Researchers developed an in situ gel using locust bean gum (LBG) that can adhere to the eye and release the antibiotic ofloxacin, which becomes a gel at body temperature.
  • Testing on rat eyes showed that the LBG-based gel not only delivered the drug effectively but also healed bacterial infections completely, suggesting its potential for future ocular drug delivery applications.
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The selection of quality excipients is a crucial step in peptide formulation development. Apart from excipient incompatibility, process-related impurities or degradants of an excipient can interact with peptide-active pharmaceutical ingredients, forming the interaction products. The formaldehyde has been reported as an impurity of excipient in polyethylene glycol, glycerol, magnesium stearate, microcrystalline cellulose, mannitol, etc.

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Variable-rate delivery of intravenous drugs is difficult to achieve with a tethered infusion system in a freely moving animal. Here, we present a protocol for continuous intravenous delivery of oxytocin in pregnant rats and mice. We describe steps for using an implantable, preprogrammed, microprocessor-controlled infusion pump connected to the jugular vein to induce labor.

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Myocardial infarction (MI) is serious health threat and impairs the quality of life. It is a major causative factor of morbidity and mortality. MI leads to the necrosis of cardio-myocytes, cardiac remodelling and dysfunction, eventually leading to heart failure.

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