[Effect of bioactive herbal preparations on structure of the gastric mucosa during stomach ulcer developing].

The present study was designed to determine experimentally the effect of a biologically active phytocomposition (BAP) on the gastric mucosa structural components during the formation and healing of ulcer induced by a single intraperitoneal injection of epinephrine. Experiments were conducted using 160 Wistar albino male rats. The fundic mucosa was studied 2, 5 and 10 days after the beginning of the experiment.

[Changes in the rate of lecithin cholesterol acyltransferase reaction and lipid indicators of serum under the effect of cathergene in acute experimental liver damage].

Fractional and molar rates of lecithin:cholesterol aminotransferase (LCAT)-catalyzed reaction were decreased, while free cholesterol fraction was increased in blood serum of rats within 24 hrs after single administration of CCl4 I mg/kg. Cathergene, contributing to a decrease in hepatocyte necrosis, affected positively the blood lipid spectrum in CCl4 treated rats. The cathergene protective effect, observed also after acute ethanol poisoning (6 g/kg), involved an increase by about 30% of the fractional and molar rates of LCAT-reactions; it also normalized the cholesterol esterification coefficient in blood serum.

[Angio-protective effect of catergen in experimental liver injury].

The 120 male rats were exposed to CCl4(1 mg/kg) or ethanol (6 g/kg) to produce acute liver injury. Previous injection of cathergen (+)-cyanidonol-3) decreased the region of hepatocytes necrosis, stabilized microvessels diameter and increased muss cells degranulation. These results indicate hepatoprotective and angioprotective effect of cathergen, more expressed in exposure CCl4.

[Lecithin-cholesterol-acyltransferase activity in chronic liver diseases].

Activity of lecithin-cholesterol-acyl transferase (LCAT) was distinctly decreased in chronic impairments of liver tissue, especially under conditions of liver cirrhosis and hepatocellular cancer. After treatment with "essentiale forte" the enzymatic activity was elevated only in the patients with chronic hepatitis. The LCAT activity correlated with content of albumins, gamma-globulins and the data of thymol test.