Bias in mobility datasets drives divergence in modeled outbreak dynamics.

Background: Digital data sources such as mobile phone call detail records (CDRs) are increasingly being used to estimate population mobility fluxes and to predict the spatiotemporal dynamics of infectious disease outbreaks. Differences in mobile phone operators' geographic coverage, however, may result in biased mobility estimates.

Methods: We leverage a unique dataset consisting of CDRs from three mobile phone operators in Bangladesh and digital trace data from Meta's Data for Good program to compare mobility patterns across these sources.

Impact of maternal antenatal nutrition and infection treatment interventions on Longitudinal Infant Development and Growth in rural Ethiopia: protocol of the LIDG child follow-up study.

Introduction: Maternal undernutrition and inflammation in utero may significantly impact the neurodevelopmental potential of offspring. However, few studies have investigated the effects of pregnancy interventions on long-term child growth and development. This study will examine the effects of prenatal nutrition and infection management interventions on long-term growth and neurodevelopmental outcomes of offspring.

A systematic review of using population-level human mobility data to understand SARS-CoV-2 transmission.

The emergence of SARS-CoV-2 into a highly susceptible global population was primarily driven by human mobility-induced introduction events. Especially in the early stages, understanding mobility was vital to mitigating the pandemic prior to widespread vaccine availability. We conducted a systematic review of studies published from January 1, 2020, to May 9, 2021, that used population-level human mobility data to understand SARS-CoV-2 transmission.

Interaction of methyl-CpG-binding protein 2 (MeCP2) with distinct enhancers in the mouse cortex.

Mutations in methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome. MeCP2 is thought to regulate gene transcription by binding to methylated DNA broadly across the genome. Here, using cleavage under target and release under nuclease (CUT&RUN) assays in the adult mouse cortex, we show that MeCP2 strongly binds to specific gene enhancers that we call MeCP2-binding hotspots (MBHs).

Physical Frailty Prediction Using Cane Usage Characteristics during Walking.

This study aimed to determine the characteristics of accelerations and angular velocities obtained by an inertial measurement unit (IMU) attached to a cane between older people with and without physical frailty. Community-dwelling older people walked at a comfortable speed using a cane with a built-in IMU. Physical frailty was assessed using exercise-related items extracted from the Kihon Check List.