Publications by authors named "T K Bathala"
Background: To determine outcomes of MRI-assisted radiosurgery (MARS) for salvage brachytherapy using the radioisotope Pd after various upfront treatments including surgery, external beam radiotherapy, and brachytherapy.
Methods: We retrospectively reviewed data for patients who underwent salvage MARS for intraprostatic lesions or prostate bed recurrences from 2016 to 2022. Biochemical recurrence, prostate cancer-specific, and overall survival, and the cumulative incidences of toxicities, were determined by Kaplan-Meier estimates.
Article Synopsis
- The study investigates whether adding metastasis-directed therapy (MDT) to standard-of-care (SOC) systemic therapy improves progression-free survival (PFS) in patients with oligometastatic breast cancer.
- A phase II randomized trial, EXTEND, included patients with up to five metastases and compared MDT plus SOC to SOC alone, measuring outcomes such as PFS and overall survival (OS).
- Results from 43 patients showed no significant improvement in PFS or other secondary endpoints with MDT, suggesting it may not provide additional benefit for this patient group, albeit with limitations in study size and sample diversity.
Article Synopsis
- The article reviews how effective whole-body magnetic resonance imaging (WBMRI) is for checking the spread of high-risk prostate cancer compared to other imaging methods.
- It found that WBMRI is just as good or better than CT scans for spotting cancer in lymph nodes and better than bone scans for finding cancer in bones.
- However, when it comes to detecting metastasis, new methods like PSMA PET scans are even more effective than WBMRI, so more research on costs and combining these methods is needed.
Whole-body magnetic resonance imaging for staging patients with high-risk prostate cancer.
Prostate Cancer Prostatic Dis
September 2024
Background: Staging patients with high-risk prostate cancer (HRPCa) with conventional imaging of computed tomography (CT) and bone scintigraphy (BS) is suboptimal. Therefore, we aimed to compare the accuracy of whole-body magnetic resonance imaging (WBMRI) with conventional imaging to stage patients with HRPCa.
Methods: We prospectively enrolled patients with newly diagnosed HRPCa (prostate-specific antigen ≥20 ng/ml and/or Grade Group ≥4).