Publications by authors named "T Juhasz"
Objectives: Femtosecond laser image guided high precision trabeculotomy (FLigHT) is a novel open-angle glaucoma treatment. The procedure non-invasively creates aqueous humor (AH) drainage channel from the anterior chamber (AC) to Schlemm's canal (SC) through the trabecular meshwork (TM) to decrease intraocular pressure (IOP). The purpose of this study was to develop a 3D finite element model (FEM) of the FLigHT procedure and to simulate clinical results for different drainage channel cross-sectional areas.
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- Host antimicrobial peptides (AMPs) and extracellular vesicles (EVs) are crucial for the immune system, with evidence showing that EVs can transport AMPs and that some AMPs can remove protein layers from EVs.
- A study investigated interactions between 26 AMPs and red blood cell-derived vesicles (REVs) using various advanced techniques to categorize the peptides based on their effects.
- Results indicated that some AMPs like LL-37 effectively eliminate protein layers with little harm to membranes, while others maintain cell-penetrating abilities without significant damage, offering insights into manipulating EVs for specific applications.
Purpose: This study assessed the safety and efficacy of transepithelial crosslinking (CXL) using femtosecond (FS) laser-machined epithelial microchannels (MCs) followed by UVA CXL compared to FS laser (NLO CXL) in rabbits.
Methods: The epithelium of 36 rabbits was machined to create 2- by 25-µm MCs at 400 MCs/mm2. Eyes were treated with 1% riboflavin (Rf) solution for 30 minutes, rinsed, and then crosslinked using UVA or NLO CXL.
Fungal infections with high mortality rates represent an increasing health risk. The antifungal protein 2 (NFAP2) is a small, cysteine-rich, cationic protein exhibiting potent anti- activity. As the underlying mechanism, pore formation has been demonstrated; however, molecular level details on its membrane disruption action are lacking.
View Article and Find Full Text PDFDeveloping unique mechanisms of action are essential to combat the growing issue of antimicrobial resistance. Supramolecular assemblies combining the improved biostability of non-natural compounds with the complex membrane-attacking mechanisms of natural peptides are promising alternatives to conventional antibiotics. However, for such compounds the direct visual insight on antibacterial action is still lacking.
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