Publications by authors named "T Josse"
Hepatitis E virus (HEV) is considered as an emerging zoonotic pathogen circulating in a wide range of animals. In recent decades, the genus Paslahepevirus frequently isolated in pigs were the most involved in human clinical practice. In addition, the genus Rocahepevirus have been isolated in rodents, and transmission to humans is increasingly reported worldwide, although gaps remain regarding the exposure factors.
View Article and Find Full Text PDFImproving the therapeutic management of HIV-positive persons is a major public health issue and includes better detection of drug resistance mutations (DRMs). The aim of this study was (i) to explore DRMs in HIV-1-positive persons presenting a blood viral load (VL) < 1000 genomes copies (gc)/mL, including the analyze of cerebrospinal fluid (CSF) and HIV-DNA from peripheral blood mononuclear cells using ultradeep sequencing (UDS) and (ii), to evaluate how these DRMs could influence the clinical practices. For each patient (n = 12), including five low-VL patients (i.
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- - The study investigates how maternal obesity in horses affects the health of both mares and their foals, particularly focusing on insulin resistance, inflammation, and potential complications like osteoarticular lesions.
- - It compares Obese mares (with higher body condition scores) to Normal mares during pregnancy and lactation, examining aspects like placental structure and fatty acid profiles in plasma, colostrum, and milk.
- - Findings revealed no significant differences in placental structure or fatty acid profiles between the two groups, but indicated that foals from obese mares had a more pro-inflammatory plasma fatty acid profile, suggesting altered placental lipid metabolism.
Article Synopsis
- Clinical exome sequencing (CES) is a cost-effective method for analyzing disease-related genes, showing a diagnostic yield of about 37.6% in a study of 603 patients with various Mendelian phenotypes.
- Key factors that predicted the utility of CES included the presence of severe phenotypes, having at least one family member tested, and prescriptions made by genetic experts.
- The findings from this study suggest that using CES as a first-level genetic test can enhance diagnostic efficiency in detecting monogenic disorders.
Bracoviruses and ichnoviruses are endogenous viruses of parasitic wasps that produce particles containing virulence genes expressed in host tissues and necessary for parasitism success. In the case of bracoviruses the particles are produced by conserved genes of nudiviral origin integrated permanently in the wasp genome, whereas the virulence genes can strikingly differ depending on the wasp lineage. To date most data obtained on bracoviruses concerned species from the braconid subfamily of Microgastrinae.
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