Pharmacokinetics of HI-6 and atropine in anaesthetized pigs after administration by a new autoinjector.

A newly developed autoinjector (Astra Tech, Sweden) containing 500 mg HI-6 and 2 mg atropine sulphate was tested in anaesthetized normal pigs. The pharmacokinetics and pharmacodynamics of the drugs after administration by the autoinjector were compared with those after conventional needle and syringe delivery intramuscularly and intravenously. Cardiopulmonary parameters were monitored and serum concentrations of oxime, atropine, and acetylcholinesterase were determined in blood samples taken at intervals over a 6 h period postinjection.

Treatment of organophosphate poisoning in pigs: antidote administration by a new binary autoinjector.

The therapeutic effectiveness of a new binary autoinjector containing 500 mg HI-6 and 2 mg atropine sulphate was tested in anesthetized pigs poisoned by a lethal dose of soman i.v. (9 micrograms/kg per 20 min).

Termination in posterior and anterior cerebellum of a climbing fibre pathway activated from the nucleus of Darkschewitsch in the cat.

Climbing fibre projections to the C2 zone of the cerebellar cortex activated from structures in the midbrain were studied by electrophysiological technique in chloralose-anaesthetized cats. The C2 zone was identified in the paramedian lobule and in the intermediate part of the anterior lobe by peripheral nerve stimulation. Foci in the medial midbrain, which upon low intensity stimulation selectively evoked climbing fibre responses in the C2 zone, were localized by careful mapping procedures.

An excitatory pathway through dorsal columns to rubrospinal cells in the cat.

A somaesthetic excitatory pathway to rubrospinal cells, via other than cortico- or cerebello-rubral relays, has been demonstrated in cats, using intracellular recording techniques. After lesions of the rostral part of the cerebral cortex and the cerebellum, electrical stimulation of the contralateral forepaw and low intensity stimulation of the dorsal columns produced excitatory post-synaptic potentials (e.p.

Cerebral cortical areas of origin of excitation and inhibition of rubrospinal cells in the cat.

The relations between the cerebral cortex and the red nucleus have been studied in acute, chloralose anaesthetized cats using intracellular recording techniques. Stimulation of the cerebral cortex induces in rubrospinal cells a short latency excitation followed by a long lasting silent period. The evidence is presented that at least a great part of the latter is due to genuine IPSP evoked in these cells.