Publications by authors named "T Jansson"
Pregnancies complicated by maternal obesity are characterized by metabolic differences affecting placental nutrient transport and fetal development. Docosahexaenoic acid (DHA) is critical for fetal brain development and is primarily incorporated into phosphatidylcholine (PC). Recent evidence suggests choline may enhance PC-DHA synthesis; however, data on the impact of maternal plasma choline on placental phospholipid DHA content in females with obesity are limited.
View Article and Find Full Text PDFThe effects of galactic cosmic radiation on reproductive physiology remain largely unknown. We determined the impact of near-continuous low-dose-rate Californium-252 neutron irradiation (1 mGy/day) as a space-relevant analog on litter size and number of resorptions at embryonic day (E) 12.5 (n = 19 radiated dams, n = 20 controls) and litter size, number of resorptions, fetal growth, and placental signaling and transcriptome (RNA sequencing) at E18.
View Article and Find Full Text PDFDesign of a Phantom Mimicking Rectal Lymph Nodes for Magnetomotive Ultrasound.
Ultrasound Med Biol
January 2025
Article Synopsis
- - The study addresses the need for a reliable phantom to test the new magnetomotive ultrasound technique, specifically designed to simulate nanoparticle-laden lymph nodes in fat for rectal cancer staging.
- - A composite material was created using styrene-butylene/ethylene-styrene in mineral oil with glass beads, and included a polyvinyl alcohol insert with magnetic nanoparticles, which closely mimicked the acoustic properties of real lymph nodes and surrounding fat.
- - The resulting phantom showed stable performance and accurate reflection rates over three weeks, indicating its potential as a useful tool for validating the magnetomotive ultrasound method and possibly other tissue-mimicking applications.
Article Synopsis
- * Low levels of adiponectin in obese pregnant women are associated with higher birth weights, and normalizing these levels in animal models can prevent issues like placental dysfunction and related diseases in offspring.
- * Research suggests that increasing the expression of the adiponectin receptor 2 (Adipor2) specifically in placentas reduces nutrient transport and fetal growth, indicating that low adiponectin levels contribute to complications in pregnancies affected by maternal obesity.
Maternal obesity increases the risk of cardiovascular and metabolic disease in the offspring both during childhood and adult life. Pregnant women and mice with obesity have lower circulating levels of adiponectin (ADN) compared to lean controls. ADN is an adipokine involved in regulating energy metabolism, vascular function, and placental function.
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