C5a-C5aR1 axis mediates lung inflammation and fibrosis induced by single-walled carbon nanotubes via promoting neutrophils recruitment.

A mounting number of studies have been documenting strong pro-inflammatory and pro-fibrotic effects of carbon nanotube (CNT). However, the molecular mechanisms of single-walled CNT (SWCNT)-provoked lung injury remain to be elucidated. Here, we established a mice model of SWCNT-induced lung injury by intratracheal instillation and found that C5a-C5a receptor-1 (C5aR1) signaling was significantly activated along with abundant neutrophils recruitment in lungs at early phase post SWCNT administration, which were positively correlated with early lung inflammation and late pulmonary fibrosis.

Basic Science and Pathogenesis.

Background: Frontotemporal degeneration (FTD) and amyotrophic lateral sclerosis (ALS) constitute a clinicopathologic spectrum with multifaceted heterogeneities. Brain transcriptomics may help to identify molecular subtypes of FTD and/or ALS but this testing is only possible at autopsy and thus is cross-sectional and representative of end-stage disease. Subtype and Stage Inference (SuStaIn) is an unsupervised machine-learning algorithm that was employed to identify temporal dynamics of data-driven subtypes of ALS and FTD.

Electrochemical Biosensing Technologies for Neurochemicals: Recent Advances in Electrochemical Sensors and Devices.

electrochemical sensing of neurotransmitters, neuromodulators, and metabolites plays a critical role in real-time monitoring of various physiological or psychological processes in the central nervous system. Currently, advanced electrochemical biosensors and technologies have been emerging as prominent ways to meet the surging requirements of monitoring of neurotransmitters and neuromodulators ranging from single cells to brain slices, even the entire brain. This review introduces the fundamental working principles and summarizes the achievements of electrochemical biosensing technologies including voltammetry, amperometry, potentiometry, field-effect transistor (FET), and organic electrochemical transistor (OECT).

PDIA4 targets IRE1α/sXBP1 to alleviate NLRP3 inflammasome activation and renal tubular injury in diabetic kidney disease.

The role of ER stress in the pathogenesis of diabetic kidney diseases (DKD) remains unclear. We employed bioinformatics to identify the UPR pathway activation, inflammation, and programmed cell death patterns in diabetic tubules. Levels of IRE1α/sXBP1 signaling, NLRP3 inflammasome activity and pyroptosis in tubular cells under high glucose conditions were measured.

Machine Learning Reveals Aneuploidy Characteristics in Cancers: The Impact of BEX4.

Background: Aneuploidy is crucial yet under-explored in cancer pathogenesis. Specifically, the involvement of brain expressed X-linked gene 4 () in microtubule formation has been identified as a potential aneuploidy mechanism. Nevertheless, 's comprehensive impact on aneuploidy incidence across different cancer types remains unexplored.