Primitive macrophages induce sarcomeric maturation and functional enhancement of developing human cardiac microtissues via efferocytic pathways.

Yolk sac macrophages are the first to seed the developing heart, however we have no understanding of their roles in human heart development and function due to a lack of accessible tissue. Here, we bridge this gap by differentiating human embryonic stem cells (hESCs) into primitive LYVE1 macrophages (hESC-macrophages) that stably engraft within contractile cardiac microtissues composed of hESC-cardiomyocytes and fibroblasts. Engraftment induces a human fetal cardiac macrophage gene program enriched in efferocytic pathways.

Arrhythmogenic Ventricular Remodeling by Next-Generation Bruton's Tyrosine Kinase Inhibitor Acalabrutinib.

Cardiac arrhythmias remain a significant concern with Ibrutinib (IBR), a first-generation Bruton's tyrosine kinase inhibitor (BTKi). Acalabrutinib (ABR), a next-generation BTKi, is associated with reduced atrial arrhythmia events. However, the role of ABR in ventricular arrhythmia (VA) has not been adequately evaluated.

Imbalanced medical disease dataset classification using enhanced generative adversarial network.

In general, the imbalanced dataset is a major issue in health applications. The medical data classification faces the imbalanced count of data samples, here at least one class forms only a very small minority of the data, but it is a drawback of most of the machine learning algorithms. The medical datasets are mostly imbalanced in its class labels.

COVID 19 an infectious disease influenced in modern era - recent survey in India.

The virus which is called as corona spoiling many of human lives as well as countries growth. Coronavirus is an infectious disease, so spreading from one person to other easily. Till now there is no medicine for corona.