Publications by authors named "T Jagielski"
Background: Plastids are usually involved in photosynthesis, but the secondary loss of this function is a widespread phenomenon in various lineages of algae and plants. In addition to the loss of genes associated with photosynthesis, the plastid genomes of colorless algae are frequently reduced further. To understand the pathways of reductive evolution associated with the loss of photosynthesis, it is necessary to study a number of closely related strains.
View Article and Find Full Text PDFBackground: Protothecosis in dogs is a rare, yet emerging disease, distinguished by its often-aggressive clinical course and high fatality rate. Our study was conducted to enhance treatment protocols for affected dogs by better understanding the genetic diversity and drug resistance patterns of Prototheca species.
Objectives: To identify species and drug susceptibility profiles of an international collection of 28 Prototheca strains isolated from cases of protothecosis in dogs.
Medically important pathogenic fungi invade vertebrate tissue and are considered primary when part of their nature life cycle is associated with an animal host and are usually able to infect immunocompetent hosts. Opportunistic fungal pathogens complete their life cycle in environmental habitats or occur as commensals within or on the vertebrate body, but under certain conditions can thrive upon infecting humans. The extent of host damage in opportunistic infections largely depends on the portal and modality of entry as well as on the host's immune and metabolic status.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluates whole-genome sequencing (WGS) as a method for detecting multi-drug resistant Mycobacterium tuberculosis strains in Poland and Lithuania, highlighting its effectiveness compared to traditional drug susceptibility testing (DST).
- Researchers analyzed 208 MTBC strains and found a 5.3% discordance rate among the results from various resistance detection methods, including WGS and molecular assays.
- Key findings indicated that resistance mutations mainly occurred in the rpoB gene, with a consistent MIC distribution for rifampicin, suggesting that WGS can provide reliable insights but may not always align perfectly with conventional techniques.