Pathophysiology of shock and hemorrhage in a fulminating viral infection (Ebola).

Eleven rhesus monkeys were monitored intensively during experimental infection with Ebola virus. Prominent neutrophilia with left shift and lymphopenia were the earliest abnormalities and were statistically significant by day 4 (P less than .02 and P less than .

Preliminary report on arbovirus-antibody prevalence among patients in Kuwait: evidence of Congo/Crimean virus infection.

From two major hospitals in Kuwait 502 sera were randomly selected from patients during the period December 1979 to October 1982. Serological investigations demonstrated Flavivirus activity in the area and antibody to Congo/Crimean haemorrhagic fever virus was found in 4% of the samples. Clinical data indicate that some cases may have been due to recent Congo/Crimean virus infection.

A case of Lassa fever: clinical and virological findings.

Five days after arriving in London from Jos a young Nigerian women developed a severe and prolonged illness that proved to be Lassa fever. Virus was not detected in urine during the first three weeks but then appeared and reached a peak during the sixth week, with continuing excretion for 67 days after the onset of illness. Laboratory investigations showed evidence of extensive tissue damage and disturbance of clotting, but there was no serious bleeding and she eventually made a complete recovery despite a high sustained viraemia and severe liver damage.