Publications by authors named "T J Slowik"
The N-methyl-D-aspartate (NMDA) glutamate receptor is a major target of ethanol, and it is implicated in learning and memory formation, and other cognitive functions. Glycine acts as a co-agonist for this receptor. We examined whether Org24598, a selective inhibitor of glycine transporter1 (GlyT1), affects ethanol withdrawal-induced deficits in recognition memory (Novel Object Recognition (NOR) task) and spatial memory (Barnes Maze (BM) task) in rats, and whether the NMDA receptor glycine site participates in this phenomenon.
View Article and Find Full Text PDFRecombinant Antibody-Producing Stable CHOK1 Pool Stability Study.
Monoclon Antib Immunodiagn Immunother
August 2024
Mammalian cell line stability is an important consideration when establishing a biologics manufacturing process in the biopharmaceutical and diagnostics (IVD) industries. Traditional Chinese hamster ovary (CHO) cell line development methods use a random integration approach that requires transfection, selection, optional amplification, screenings, and single-cell cloning to select clones with acceptable productivity, product quality, and genetic stability. Site-specific integration reduces these disadvantages, and new technologies have been developed to mitigate risks associated with genetic instability.
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- The study investigates the effects of Cannabidiol (CBD) on drug-taking behavior in adolescent rats, particularly focusing on its potential to reduce the reinstatement of oxycodone-induced conditioned place preference (CPP).
- Findings indicate that CBD effectively prevents reinstatement of CPP only in adolescent males, linked to changes in specific brain receptors (increased cannabinoid 1 and decreased mu opioid receptors), while similar effects were not observed in females.
- The research suggests that CBD may have gender-specific impacts on opioid-seeking behavior and cognition, emphasizing the need for further studies to understand these differences better.
Linagliptin is a selective dipeptidyl peptidase-4 (DPP-4) inhibitor that indirectly elevates the glucagon-like peptide-1 (GLP-1) level. The aim of the present study was to check whether linagliptin has an influence on neurotransmission in rat brain. Rats were acutely and chronically exposed to linagliptin (10 and 20 mg/kg, intraperitoneally (i.
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- Children with fetal alcohol spectrum disorders (FASDs) show social functioning issues that lead to school withdrawal, delinquency, and increased anxiety and depression.
- A study using rats found that those exposed to ethanol at birth displayed specific social recognition memory deficits linked to age and sex.
- Treatment with CE-123, a dopamine reuptake inhibitor, helped prevent these social deficits and increased neuroplasticity in the hippocampus of the affected rats, suggesting potential for treating FASD-related social behavior problems.