Publications by authors named "T J Rutherford"
Article Synopsis
- - Uterine leiomyomas, affecting up to 80% of women, cause issues like abnormal bleeding, pelvic pain, and infertility, but their growth mechanisms are not well understood.
- - Research showed that uterine leiomyomas had lower levels of CD73 expression and adenosine compared to healthy myometrium, suggesting a link to tumor growth regulation.
- - Experiments indicated that adding adenosine or certain receptor agonists inhibited the growth of leiomyoma cells by promoting cell death and reducing key protein expressions, proposing new treatment approaches for these tumors.
Medium-chain fatty acids (MCFAs), particularly decanoic acid (C10) and octanoic acid (C8), have garnered attention in recent years for their potential antiepileptic properties. A previous study from our laboratory demonstrated that C10 targets the PPARγ nuclear receptor, increasing the activity of the antioxidant enzyme catalase and thereby possibly modulating peroxisomal content. Here, we examined markers of peroxisomal content and activity in response to C10 and C8 exposure in neuronal-like SH-SY5Y cells.
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- LARPs are RNA-binding proteins with a conserved La motif domain, and LARP1 specifically regulates ribosomal protein synthesis and mRNA stability without a standard RNA binding domain.
- The study found that LARP1 shows a unique preference for recognizing singly guanylated poly(A) sequences, without increased affinity for multiple guanines.
- High-resolution crystal structures and isothermal titration measurements revealed that LARP1 also binds cyclic di-nucleotides with strong affinity, suggesting its role in stabilizing poly(A) tails influenced by guanylation.
Article Synopsis
- VEGFR2 is crucial for directing blood vessel formation in the placenta, and a study identified proteins MDMX and PICALM as key partners in its function.
- Immunological methods showed the presence of several receptors, including the oxytocin receptor, in cells associated with angiogenesis and placenta function, suggesting novel pathways for fetal communication.
- The research indicated a link between certain protein levels and pregnancy complications like preeclampsia, as well as differences in protein expressions among various delivery methods, highlighting potential implications for maternal and neonatal health.
Cocoa butter equivalents (CBE) are mixtures of triglycerides from multiple sources (e.g., sunflower oil, mango kernel and sal), which resemble cocoa butter (CB) in both physical and chemical properties.
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