Publications by authors named "T J Moore"
Effective chronic disease prevention requires a systems approach to the design, implementation, and refinement of interventions that account for the complexity and interdependence of factors influencing health outcomes. This paper proposes the Participatory Implementation Systems Mapping (PISM) process, which combines participatory systems modeling with implementation strategy development to enhance intervention design and implementation planning. PISM leverages the collaborative efforts of researchers and community partners to analyze complex health systems, identify key determinants, and develop tailored interventions and strategies that are both adaptive and contextually relevant.
View Article and Find Full Text PDFEbola and Marburg (EBOV and MARV) filoviral infections lead to fatal hemorrhagic fevers and have caused over 30 outbreaks in the last 50 years. Currently, there are no FDA-approved small molecule therapeutics for effectively treating filoviral diseases. To address this unmet medical need, we have conducted a systematic structural optimization of an early lead compound, -(4-(4-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-4-(morpholinomethyl)benzamide (), borne from our previously reported hit-to-lead effort.
View Article and Find Full Text PDFA 66-year-old female presented to the hospital for evaluation of multiple strokes over a three-month period. The patient underwent extensive testing to evaluate for autoimmune vasculitis and other hypercoagulable entities that were negative. Bone marrow and lymph node biopsies showed no evidence of lymphoma.
View Article and Find Full Text PDFArticle Synopsis
- Recent advancements in extracellular vesicle (EV) biology are recognized for their potential impact on health and disease, particularly in vision research.
- The National Eye Institute (NEI) highlighted EV research in its 2021-2025 Strategic Plan as a key focus area within Regenerative Medicine.
- A workshop was held with twenty experts to assess the state of EV research and identify opportunities for its application in diagnosing and treating eye diseases.
Article Synopsis
- Social stress can increase oxidative stress in the brain, potentially leading to mental health disorders, with previous studies showing that social hierarchies impact this stress.
- In a study of cichlid fish, researchers found that dominant males (who are territorial and reproductively active) had lower oxidative DNA damage in the midbrain and greater antioxidant capacity compared to subordinate males.
- The findings suggest that social status and reproductive activity influence oxidative balance in the brain, but the effects vary across different brain areas.