Publications by authors named "T J Mancuso"

Purpose: Practice is shifting toward genome-first approaches, such as opportunistic screening for secondary findings (SFs). Analysis of SFs could be extended beyond medically actionable results to include non-medically actionable monogenic disease risks, carrier status, pharmacogenomic variants, and risk variants for common complex disease. However, evidence on the clinical utility of returning these results is lacking.

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Current concerns regarding the health and environmental consequences associated with excessive meat consumption have underscored the importance of guiding consumers towards more sustainable diets. Given this perspective, this study seeks to evaluate the effectiveness of tailored informative messages in shaping consumer behaviour, particularly within the framework of replacing meat with mushroom-based alternatives. Additionally, it explores the factors influencing informative message effectiveness.

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The agribusiness sector is constantly seeking solutions to enhance food security, sustainability, and resilience. Recent estimates indicate that one-third of the total food production remains unused due to waste or limited shelf life, resulting in negative environmental and ethical consequences. Consequently, exploring technological solutions to extend the shelf life of food products could be a crucial option to address this issue.

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Article Synopsis
  • Mitochondrial alterations are linked to various cancers, including multiple myeloma (MM), and natural flavonoids like Hesperetin and Naringenin are studied for their potential to target mitochondrial dynamics by affecting the protein Drp1.
  • The study involved multiple methods such as molecular docking, cell viability tests, and transcriptomic analyses to explore how Hes and Nar influence MM cells, including effects on cell growth and apoptosis.
  • Results showed that Hes and Nar inhibit Drp1, leading to changes in mitochondrial structure, reduced cancer cell survival and growth, and altered cellular metabolism by down-regulating key transcription factors involved in lipogenesis.
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