Publications by authors named "T J M Welting"
Purpose: Knee joint distraction is a surgical procedure with cartilage-regenerating properties. The composition of joint distraction-regenerated cartilage in human patients is poorly documented. In this case-study, provided a unique opportunity to biomolecularly characterize the regenerated tissue from a patient who underwent bilateral distraction and later knee replacements.
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- The study aimed to differentiate osteoarthritis (OA) patients by analyzing their serum-induced cellular signaling patterns, using samples from knee OA patients, hand OA patients, and healthy controls.
- Results showed significant differences in cellular pathway activity based on the type of OA, with hand OA serum triggering higher MAPK-related AP1 activity, while knee OA serum affected other pathways related to ELK1-SRF, STAT1-STAT2, and SOX9.
- The findings suggest that the underlying mechanisms of OA differ between hand and knee OA, potentially paving the way for more targeted treatments based on specific OA endotypes.
Objectives: To develop a protocol for largescale analysis of synovial fluid proteins, for the identification of biological networks associated with subtypes of osteoarthritis.
Methods: Synovial Fluid To detect molecular Endotypes by Unbiased Proteomics in Osteoarthritis (STEpUP OA) is an international consortium utilising clinical data (capturing pain, radiographic severity and demographic features) and knee synovial fluid from 17 participating cohorts. 1746 samples from 1650 individuals comprising OA, joint injury, healthy and inflammatory arthritis controls, divided into discovery (n = 1045) and replication (n = 701) datasets, were analysed by SomaScan Discovery Plex V4.
Patient-specific instrumentation improved clinical outcome and implant survival but is not superior compared to conventional total knee arthroplasty: Ten years follow-up of a multicenter double-blind randomized controlled trial.
Knee Surg Sports Traumatol Arthrosc
October 2024
Article Synopsis
- ) Patient-specific instrumentation (PSI) was studied to see if it improves outcomes in total knee arthroplasty (TKA) compared to conventional instruments (CIs), but long-term results had been lacking.
- ) In a 10-year follow-up of a randomized controlled trial involving patients with knee osteoarthritis, both PSI and CI groups showed similar clinical outcomes and revision rates, with no significant differences.
- ) The study concluded that PSI did not provide better clinical outcomes or prosthesis survival compared to conventional methods over the 10-year period.
Article Synopsis
- Raman spectroscopy is introduced as an advanced method for identifying specific crystals (monosodium urate and calcium pyrophosphate) in synovial fluid, but its interpretation typically requires expertise that clinicians may lack.
- A machine learning approach was developed to automate the classification of Raman spectra from synovial fluid samples collected from 446 patients, using training and validation datasets to improve accuracy.
- The trained model achieved high classification accuracies (up to 96% for CPP and 92.5% for MSU), demonstrating its effectiveness in distinguishing pathological crystals from other particles, thus providing a more objective diagnostic tool for clinicians.