Publications by authors named "T J Lloyd"
Background: We developed a prototype minimum data set (MDS) for English care homes, assessing feasibility of extracting data directly from digital care records (DCRs) with linkage to health and social care data.
Methods: Through stakeholder development workshops, literature reviews, surveys and public consultation, we developed an aspirational MDS. We identified ways to extract this from existing sources, including DCRs and routine health and social care datasets.
Introduction: Information on care home residents in England is captured in numerous data sets (care home records, General Practitioner records, community nursing, etc.) but little of this information is currently analysed in a way that is useful for care providers, current or future residents and families or that realises the potential of data to enhance care provision. The DACHA study aimed to develop and test a minimum data set (MDS) which would bring together data that is useful to support and improve care and facilitate research.
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- The study investigates inclusion body myositis (IBM), focusing on the role of TDP-43 protein and its implications in muscle pathology.
- It found that cryptic peptides linked to TDP-43 were present in 65% of muscle biopsies from IBM patients, but absent in other controls, indicating potential as a biomarker for IBM.
- The findings suggest that restoring TDP-43 function might help slow down muscle degeneration in patients with this disease.
Background: Musculoskeletal diseases are a major contributor to global human disability, but research in this area of medicine contends with chronic underfunding in the United States, receiving <2% of the National Institutes of Health (NIH) budget. The Orthopaedic Research and Education Foundation (OREF) serves as a vital nongovernmental organization, providing essential support for orthopaedic research. This study investigated the translation of various OREF grants into successful extramural federal funding discerning the clinician demographics and OREF award characteristics associated with increased chances of securing federal grants.
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- TDP-43 is an RNA binding protein that forms aggregates in the central nervous system and is notably present in certain neurodegenerative diseases and inclusion body myopathy, a type of muscle disease.
- Researchers developed a mouse model that shows muscle weakness associated with TDP-43 accumulation, which indicates a prion-like spread of the protein possibly affecting muscle tissues.
- Human muscle biopsies from patients with various conditions, especially inclusion body myositis (IBM), contain TDP-43 aggregate seeds, suggesting a unique pathogenic role for TDP-43 in muscle diseases that wasn't fully recognized before.