Publications by authors named "T J Lehman"
Article Synopsis
- Deucravacitinib is a new oral medication that selectively inhibits a protein involved in inflammatory processes, showing better results than a placebo in treating psoriatic arthritis during a phase 2 clinical trial.
- In the trial, 203 patients were split into three groups: one received a placebo, while two groups received different doses of deucravacitinib. The study measured how many patients met the criteria for a state called "minimal disease activity" after 16 weeks.
- Results indicated that more patients taking deucravacitinib achieved the necessary criteria for individual components of minimal disease activity compared to those on placebo, showing that the treatment was effective over the 16-week period.
Objective: Deucravacitinib, a tyrosine kinase 2 inhibitor, was assessed in a phase 2 trial in patients with active psoriatic arthritis (PsA). Here, we report effects of deucravacitinib from the patient perspective.
Methods: This phase 2, double-blind trial (NCT03881059) randomized patients with active PsA 1:1:1 to deucravacitinib 6 mg once daily (QD), 12 mg QD, or placebo, for 16 weeks.
Article Synopsis
- Chronic postsurgical pain (CPSP) is a significant issue requiring further research to understand its incidence, characteristics, and risk factors, particularly after various surgeries like breast cancer operations and knee arthroplasties.
- An extensive observational study involved 3,297 patients from 18 European hospitals, revealing a 6-month CPSP incidence rate of 10.5%, with variations based on surgery type, and highlighting a common occurrence of neuropathic pain symptoms.
- While the study did not succeed in creating a new predictive score for CPSP, it provided valuable insights into its prevalence and impact on patients' quality of life following different surgical procedures.
Circulating miRNAs the in blood are promising biomarkers for predicting pregnancy complications and adverse birth outcomes. Previous work identified 11 gestationally elevated maternal circulating miRNAs (HEamiRNAs) that predicted infant growth deficits following prenatal alcohol exposure and regulated epithelial-mesenchymal transition in the placenta. Here we show that a single intravascular administration of pooled murine-conserved HEamiRNAs to pregnant mice on gestational day 10 (GD10) attenuates umbilical cord blood flow during gestation, explaining the observed intrauterine growth restriction (IUGR), specifically decreased fetal weight, and morphometric indices of cranial growth.
View Article and Find Full Text PDFHere, we discover a player in root development. Recovered from a forward-genetic screen in Brachypodium distachyon, the buzz mutant initiates root hairs but they fail to elongate. In addition, buzz roots grow twice as fast as wild-type roots.
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