A voice-activated integrated development environment for manually disabled programmers.

Purpose: The paper presents the design and implementation of voice-based interface to support two types of application development activities (coding, and visual GUI design) by manually disabled programmers.

Method: Prototype programs were implemented, and tests were performed for both proposed voice-based interface models.

Results: The interface design concepts, and the results and lessons learned of the usability studies are discussed.

Fatty acid binding protein: stimulation of microsomal phosphatidic acid formation.

The effect of fatty acid binding proteins (FABPs) on two key steps of microsomal phosphatidic acid formation was examined. Rat liver microsomes were purified by size-exclusion chromatography to remove endogenous cytosolic fatty acid and fatty acyl-CoA binding proteins while recombinant FABPs were used to avoid cross-contamination with such proteins from native tissue. Neither rat liver (L-FABP) nor rat intestinal fatty acid binding protein (I-FABP) stimulated liver microsomal fatty acyl-CoA synthase.

Isolation and characterization of two fatty acid binding proteins from mouse brain.

Two fatty acid binding proteins (FABPs) were isolated from Swiss Webster mouse brains. Neither protein cross-reacted with antisera to recombinant liver L-FABP. One protein, designated brain H-FABP, migrated on tricine sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) as a single band at 14.

Expression of liver fatty acid binding protein in L-cells: plasma membrane response to ethanol.

Expression of liver fatty acid binding protein (L-FABP) in transfected L-cell fibroblasts modifies plasma membrane structure and function [Incerpi et al., 1992, Arch. Biochem.