Publications by authors named "T J Gana"
Background: We evaluated the frequency of genomic testing and treatment patterns by age category in patients with newly diagnosed (ND) acute myeloid leukemia (AML) treated in both academic- and community-based health systems within a single Midwestern State.
Methods: Retrospective analysis of data from the Indiana University Health System Enterprise Data Warehouse and two local cancer registries, of 629 patients aged ≥18 years with ND AML during 2011-2018. Primary outcome variables were, proportion of patients with genomic analysis and frequency of mutations.
Background: Patients with acute myeloid leukemia (AML) who have tumor protein p53 (TP53) mutations or a complex karyotype have a poor prognosis, and hypomethylating agents are often used. The authors evaluated the efficacy of entospletinib, an oral inhibitor of spleen tyrosine kinase, combined with decitabine in this patient population.
Methods: This was a multicenter, open-label, phase 2 substudy of the Beat AML Master Trial (ClinicalTrials.
Article Synopsis
- The study investigates the effectiveness of early bowel resection (EBR) for ileocaecal Crohn's disease compared to traditional medical therapy (MT) and concludes that EBR may offer better outcomes.
- A systematic review of eight studies found that patients undergoing EBR had a significantly lower need for drug therapy and a reduced rate of intestinal resection over five years compared to those on MT.
- The findings suggest that EBR leads to more stable remission and could be a viable alternative to MT in selected cases of limited ileocaecal disease.