Publications by authors named "T J Dorsey"
Importance: Racial disparities in prostate cancer are likely the result of complex relationships between both socioeconomic and environmental factors captured by the neighborhood environment and genetic factors, including West African genetic ancestry. However, few studies have examined the combined role of neighborhood environment and genetic ancestry in developing lethal prostate cancer.
Objective: To examine the interactions between West African genetic ancestry and neighborhood deprivation in modifying prostate cancer risk and mortality.
Article Synopsis
- Pancreatic ductal adenocarcinoma (PDAC) has different molecular subtypes, including a more aggressive basal-like/squamous subtype and a less aggressive classical/progenitor subtype.
- A study identified that the adrenoceptor alpha 2A (ADRA2A) gene is downregulated in the aggressive subtype and its lower expression correlates with worse patient outcomes, including more metastasis and decreased survival.
- Experimental results showed that increasing ADRA2A levels can reduce characteristics of the aggressive subtype while enhancing those of the less aggressive subtype, suggesting it could be a valuable target for diagnosis and treatment in PDAC.
Article Synopsis
- Immune therapy is becoming a key approach in cancer treatment, particularly for aggressive types like triple negative breast cancer (TNBC), where factors like COX2 limit treatment effectiveness.
- A study revealed that combining radiation with the anti-inflammatory drug indomethacin significantly boosted the immune response, reduced tumor growth, and lowered metastasis in mouse models of TNBC.
- The combination treatment led to better local control of tumors and increased survival rates by enhancing immune activity, suggesting that existing NSAIDs could improve the success of radiation therapy in cancer patients.
Pancreatic ductal adenocarcinoma (PDAC) manifests diverse molecular subtypes, including the classical/progenitor and basal-like/squamous subtypes, with the latter known for its aggressiveness. We employed integrative transcriptome and metabolome analyses to identify potential genes contributing to the molecular subtype differentiation and its metabolic features. Transcriptome analysis in PDAC patient cohorts revealed downregulation of adrenoceptor alpha 2A (ADRA2A) in the basal-like/squamous subtype, suggesting its potential role as a candidate suppressor of this subtype.
View Article and Find Full Text PDFPancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal-like/squamous PDAC. We hypothesized that integrative transcriptome and metabolome approaches can identify candidate genes whose inactivation contributes to the development of the aggressive basal-like/squamous subtype. Using our integrated approach, we identified endosome-lysosome associated apoptosis and autophagy regulator 1 (ELAPOR1/KIAA1324) as a candidate tumor suppressor in both our NCI-UMD-German cohort and additional validation cohorts.
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