A hospital and community-based violence intervention program for Black & Latino youth and their caregivers.

Background: Black and Latino youth are disproportionately affected by trauma from community violence, but to date, few data support the benefit of evidence-based treatments for these youth or of including peer support to engage these youth in mental health services.

Objective: From 2018 until 2020, a hospital and community-based violence intervention program in Philadelphia pilot tested the integration of home and community-based Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) with peer services and case management for youth impacted by community violence. This study describes the implementation of this intervention.

SYCP1 head-to-head assembly is required for chromosome synapsis in mouse meiosis.

In almost all sexually reproducing organisms, meiotic recombination and cell division require the synapsis of homologous chromosomes by a large proteinaceous structure, the synaptonemal complex (SC). While the SC's overall structure is highly conserved across eukaryotes, its constituent proteins diverge between phyla. Transverse filament protein, SYCP1, spans the width of the SC and undergoes amino-terminal head-to-head self-assembly in vitro through a motif that is unusually highly conserved across kingdoms of life.

rRNA transcription is integral to phase separation and maintenance of nucleolar structure.

Transcription of ribosomal RNA (rRNA) by RNA Polymerase (Pol) I in the nucleolus is necessary for ribosome biogenesis, which is intimately tied to cell growth and proliferation. Perturbation of ribosome biogenesis results in tissue specific disorders termed ribosomopathies in association with alterations in nucleolar structure. However, how rRNA transcription and ribosome biogenesis regulate nucleolar structure during normal development and in the pathogenesis of disease remains poorly understood.

Emergency management pandemic planning: An analysis of state emergency plans.

Conventional wisdom holds that pre-event planning is a key factor in effective disaster response. In assessing the response to the Coronavirus Disease 2019 (COVID-19) pandemic, it is necessary to evaluate the extent to which emergency management agencies were prepared to respond to a pandemic, particularly given the unusual nature of this event, ie, scope, scale, and length of response. While emergency management agencies at every level of government have been involved in the COVID-19 response, state-level governments have taken on a prominent and atypical lead-ership role.