Publications by authors named "T J Bussey"
In the mouse embryonic forebrain, developmentally distinct oligodendrocyte progenitor cell populations and their progeny, oligodendrocytes, emerge from three distinct regions in a spatiotemporal gradient from ventral to dorsal. However, the functional importance of this oligodendrocyte developmental heterogeneity is unknown. Using a genetic strategy to ablate dorsally derived oligodendrocyte lineage cells (OLCs), we show here that the areas in which dorsally derived OLCs normally reside in the adult central nervous system become populated and myelinated by OLCs of ventral origin.
View Article and Find Full Text PDFThe retrosplenial cortex (RSC) is a hub of diverse afferent and efferent projections thought to be involved in associative learning. RSC shows early pathology in mild cognitive impairment and Alzheimer's disease (AD), which impairs associative learning. To understand and develop therapies for diseases such as AD, animal models are essential.
View Article and Find Full Text PDFInterpreting three-dimensional models of biological macromolecules is a key skill in biochemistry, closely tied to students' visuospatial abilities. As students interact with these models and explain biochemical concepts, they often use gesture to complement verbal descriptions. Here, we utilize an embodied cognition-based approach to characterize undergraduate students' gesture production as they described and interpreted an augmented reality (AR) model of potassium channel structure and function.
View Article and Find Full Text PDFArticle Synopsis
- Metformin, commonly used to treat diabetes, was studied for its potential benefits in Alzheimer's disease (AD), but some research indicates it may actually increase AD risk and pathology in humans.
- In a study involving prolonged metformin administration in mice, younger non-transgenic mice showed improvements in attention and learning, while older mice faced memory retention deficits and cognitive impairments, particularly in those with AD.
- The treatment also led to increased levels of harmful AD-related proteins and decreased crucial synaptic markers, suggesting that the use of metformin for Alzheimer's patients warrants careful evaluation.
Introduction: About two-thirds of Alzheimer's Disease (AD) patients are women, who exhibit more severe pathology and cognitive decline than men. Whether biological sex causally modulates the relationship between cholinergic signaling and amyloid pathology remains unknown.
Methods: We quantified amyloid beta (Aβ) in male and female App-mutant mice with either decreased or increased cholinergic tone and examined the impact of ovariectomy and estradiol replacement in this relationship.