Publications by authors named "T J Bull"
Article Synopsis
- Pulmonary veno-occlusive disease (PVOD) is a rare pulmonary vascular condition that can be mistaken for pulmonary arterial hypertension (PAH), and they are believed to have different genetic causes.
- This report details a case of a woman diagnosed with PAH at 42, who unfortunately passed away despite treatment, and her son, who was diagnosed with PAH at 16 and required a heart-lung transplant due to worsening conditions.
- The autopsy of the mother showed evidence consistent with PAH, while the son's lung pathology confirmed PVOD, and neither had identifiable genetic mutations linked to these diseases.
The PERFECT study, a randomized, controlled, double-blind study of inhaled treprostinil in patients with COPD and associated pulmonary hypertension (PH-COPD) was a negative trial that was terminated early. The reason(s) for the negative outcome remains uncertain. A post hoc analysis of data from the PERFECT study was undertaken to identify adverse responders and possibly potential responders.
View Article and Find Full Text PDFWe describe the development, testing and specificity of a modified oligonucleotide probe for the specific detection of Mycobacterium avium subsp. paratuberculosis (MAP) in culture and in infected tissue using fluorescent in situ hybridisation and confocal microscopy. The detection of MAP in both animal and human tissue using our modified probe allows for a more rapid diagnosis of MAP infection compared to the more often applied detection methods of culture and PCR and has the potential for quantification of cellular abundance.
View Article and Find Full Text PDFBackground: Pulmonary hypertension (PH) accompanying COPD (PH-COPD) is associated with worse outcomes than COPD alone. There are currently no approved therapies to treat PH-COPD. The PERFECT study (ClinicalTrials.
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