Publications by authors named "T J Boucher"

Background: Patients are increasingly turning to the internet, and recently artificial intelligence engines (e.g., ChatGPT), for answers to common medical questions.

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Article Synopsis
  • Hepatic artery infusion (HAI) chemotherapy combined with systemic treatment shows promising long-term results for patients with intrahepatic cholangiocarcinoma (IHC), suggesting improved disease control and overall survival rates.
  • A phase II clinical trial and a retrospective analysis revealed a median progression-free survival (PFS) of 11.8 months and overall survival (OS) of 26.8 months among a subset of patients, with particular genomic alterations indicating worse outcomes.
  • The study indicates that HAI with floxuridine (FUDR) alongside systemic therapies can provide durable disease control in locally advanced IHC, while molecular changes, particularly in the TP53 pathway, might help predict patient response to treatment.
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Purpose: Autistic individuals often face challenges perceiving and expressing emotions, potentially stemming from differences in speech prosody. Here we explore how autism diagnoses between groups, and measures of social competence within groups may be related to, first, children's speech characteristics (both prosodic features and amount of spontaneous speech), and second, to these two factors in mothers' speech to their children.

Methods: Autistic (n = 21) and non-autistic (n = 18) children, aged 7-12 years, participated in a Lego-building task with their mothers, while conversational speech was recorded.

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Background: Walch B2 glenoids can present a challenge to shoulder arthroplasty surgeons. Short-term studies have demonstrated that corrective reaming to 10° of retroversion in anatomic total shoulder arthroplasty (aTSA) can result in good outcomes; however, there is little data reporting the long-term outcomes in this cohort. B2 glenoids treated with high-side reaming present a theoretical risk of early glenoid component failure as one may ream into the subchondral bone.

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Food production is at the heart of global sustainability challenges, with unsustainable practices being a major driver of biodiversity loss, emissions and land degradation. The concept of foodscapes, defined as the characteristics of food production along biophysical and socio-economic gradients, could be a way addressing those challenges. By identifying homologues foodscapes classes possible interventions and leverage points for more sustainable agriculture could be identified.

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