Publications by authors named "T J Barna"
Article Synopsis
- Aquaporins (AQPs), particularly AQP5, play a crucial role in pregnancy-related functions such as implantation and uterine contractions, though the exact mechanisms are still unclear.
- A study on late-pregnant rats showed that reducing AQP5 levels led to shorter gestational periods and increased uterine contractions, particularly after treatment with AQP5 siRNA.
- The research indicates that AQP5 interacts with the adrenergic system, which can influence uterine contractions; these insights may pave the way for new treatments to manage preterm labor.
Determining the female animal cycle is crucial in preclinical studies and animal husbandry. Changes in hormone levels during the cycle affect physiological responses, including altered contractility of the visceral smooth muscle. The study aimed to identify estrus and anestrus using smooth muscle electromyographic (SMEMG) measurements, in vivo fluorescent imaging (IVIS) and in vitro organ contractility of the uterus and cecum.
View Article and Find Full Text PDFThe multi-messenger detection of the gravitational-wave signal GW170817, the corresponding kilonova AT2017gfo and the short gamma-ray burst GRB170817A, as well as the observed afterglow has delivered a scientific breakthrough. For an accurate interpretation of all these different messengers, one requires robust theoretical models that describe the emitted gravitational-wave, the electromagnetic emission, and dense matter reliably. In addition, one needs efficient and accurate computational tools to ensure a correct cross-correlation between the models and the observational data.
View Article and Find Full Text PDFAims: Our aims were to investigate the uterus relaxant effect of sildenafil alone and co-administered with β-mimetic terbutaline in an isolated organ bath and to perform in vivo smooth muscle electromyographic studies in pregnant rats. The modifications in uterine cAMP/cGMP levels were also detected.
Main Methods: Contractions of non-pregnant and 5/15/18/20/22-day pregnant uterine rings were measured in an isolated organ bath system in the presence of sildenafil alone or with terbutaline.