Background: We aimed to determine whether elevated preoperative serum inflammatory markers influence surgical site infections (SSIs) and periprosthetic joint infections (PJIs) after primary total hip arthroplasty (THA).
Methods: In this retrospective single-institution study, 1115 patients who underwent primary THA were enrolled. Cases of SSI/PJI were identified.
Adipose-derived stem cells (ADSCs) have been studied for many years as a therapeutic option for osteoarthritis (OA); however, their efficacy remains insufficient. Since platelet-rich plasma (PRP) induces chondrogenic differentiation in ADSCs and the formation of a sheet structure by ascorbic acid can increase the number of viable cells, we hypothesized that the injection of chondrogenic cell sheets combined with the effects of PRP and ascorbic acid may hinder the progression of OA. The effects of induction of differentiation by PRP and formation of sheet structure by ascorbic acid on changes in chondrocyte markers (collagen II, aggrecan, Sox9) in ADSCs were evaluated.
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