Outcomes with a shorter multidrug-resistant tuberculosis regimen from Karakalpakstan, Uzbekistan.

Background: In 2016, World Health Organization guidelines conditionally recommended standardised shorter 9-12-month regimens for multidrug-resistant (MDR) tuberculosis (TB) treatment. We conducted a prospective study of a shorter standardised MDR-TB regimen in Karakalpakstan, Uzbekistan.

Methods: Consecutive adults and children with confirmed rifampicin-resistant pulmonary TB were enrolled between September 1, 2013 and March 31, 2015; exclusions included prior treatment with second-line anti-TB drugs, and documented resistance to ofloxacin or to two second-line injectable agents.

Effectiveness of miltefosine in cutaneous leishmaniasis caused by Leishmania tropica in Pakistan after antimonial treatment failure or contraindications to first line therapy-A retrospective analysis.

Background: Cutaneous leishmaniasis (CL) is a neglected tropical skin disease, caused by Leishmania protozoa. In Pakistan, where CL caused by L. tropica is highly endemic, therapy with pentavalent antimonials is the standard of care, but has significant toxicity when used in systemic therapy, while are no evidence-based safer alternative treatment options for L.

[Application of ultrasonographic investigation and computer tomography in diagnosis and the treatment method choice of complex postoperative hernias of the abdominal wall].

The work is based on analysis of the results of the abdominal hernia (AH) and the anterior abdominal wall state investigation in 48 patients of the main group and in 20--of a control one, using ultrasonographic examination (USE) and computer tomography (CT). The parameters of hernial localization, the hernial sac size and content, the hernial gates size and quantity, as well as the degenerative changes severity of the abdominal wall musculo-aponeurotic structures were investigated in the patients, suffering complex postoperative AH. Degenerative changes in the anterior abdominal wall musculo-aponeurotic structures, more pronounced in the patients older than 50 years, and also in the presence of large and giant AH, especially while their durable persistence, were revealed according to the USE and CT data obtained.