Publications by authors named "T Iu Krasnova"

Article Synopsis
  • - Neurodegenerative diseases like Alzheimer's and Parkinson's are increasingly common and result from a mix of genetic mutations and environmental influences, particularly oxidative stress.
  • - Vitamin K plays a complex role in the nervous system; while high levels can increase harmful reactive oxygen species, low amounts may protect cells and support the function of crucial proteins called Gla proteins.
  • - The relationship between vitamin K levels and brain health is still not fully understood, and more research might uncover new ways to use vitamin K in personalized nutrition and therapies for cognitive decline.
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The article describes major milestones in acknowledgment of pathophysiological relationship between heart and kidneys since Ancient Egypt till our time and history of term "cardiorenal syndrome" (CRS). First references about kidney and heart functions could be dated to 13 BC when Hippocrates mentioned them. In the XIV century Gentile da Foligno proposed a hypothesis about functional interconnection between heart and kidneys.

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Background: Focal segmental glomerulosclerosis (FSGS) is a primary podocytopathy characterized by primary podocyte detection and high proteinuria. The search for biomarkers and factors associated with the progression of this disease is an important task nowdays.

Aim: To assess the proteomic profile of urine in patients with FSGS and to isolate urinary biomarkers of podocytopathies.

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It is suggested that activated CD44+ cells play a profibrogenic role in the pathogenesis of active glomerulopathies. Complement activation is also involved in renal fibrogenesis. The aim of the study was to evaluate the role of the activation of CD44+ cells in the kidney tissue and complement components' filtration to the urine as factors of renal tissue fibrosis in patients with glomerulopathies.

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Article Synopsis
  • The study aimed to assess the efficacy of proactive anti-inflammatory treatments in COVID-19 patients with pneumonia and a risk of severe inflammation ("cytokine storm").
  • Participants were divided into four groups: one receiving colchicine, one receiving secukinumab, one receiving ruxolitinib, and a control group with no anti-inflammatory therapy.
  • Results showed that all three treatments significantly reduced inflammation and improved clinical outcomes, as indicated by better scores on the COVID Clinical Condition Scale and reduced lung lesion area.
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