[Evaluation of manganese-trans-1,2-diaminocyclohexane-N,N,N',N'-tetraacetate complex (Cyclomang) as paramagnetic contrast agent for magnetic resonance imaging].

Preclinical evaluation of a 0.5 M solution of the manganese(II)- trans-1,2-diaminocyclohexane-N,N,N',N'-tetraacetate complex (Mn-DCTA, Cyclomang) has been carried out with a view to substitution of potentially toxic gadolinium-containing paramagnetic contrast agents for clinical MRI routines. The toxicological tests of Mn(II)-DCTA were performed on mice and rats.

Pharmacology of somatrotropin pegylated by electron-beam synthesis nanotechnology.

Pharmacological characteristics of somatotropin pegylated using electron-beam synthesis nanotechnology (PEG-STH) were studied. Oral PEG-STH stimulated the intensity of protein and lipid metabolism and endochondral bone growth without modifying the processes of periosteal and endosteal bone formation. Specific activity of this substance administered orally significantly surpassed that of parenteral non-modified growth hormone.

[Hepatotoxicity of antineoplastic agents].

The influence of various antineoplastic preparations (farmorubicin, paclitaxel, etoposide, platidiam) on morphological and functional status of the liver in experimental animals was studied. It is shown, that all these antineoplastic drugs possess strong hepatotoxic activity and thereby cause toxic hepatitis and increase activity of hepatic enzymes. Biochemical parameters were normalized within 30 days after treatment whereas morphological changes persisted somewhat longer.

[Preclinical toxicological evaluation of Pentamang and Mangascan].

We have carried out a preclinical toxicological investigation (acute toxicity evaluation) of Mangascan (0.5 M solution of manganese(II) - EDTA complex) and Pentamang (0.5 M solution of manganese(II) - DTPA complex), a new paramagnetic contrast agents for MRI procedures.

[Myelotoxity of the nuclear enzyme inhibitors irinotecan and etoposide].

Irinotecan (campto) and etoposide cause the loss cells due to apoptosis, the early development of hypoplasia in bone marrow and lymphoid organs, and pancytopenia in peripheral blood upon single intravenous injection in maximum tolerated doses to white outbred rats. Etoposide causes more severe apoptosis and myelotoxicity than irinotecan. The changes are reversible within one to three months.