[The prenatal manifestations of peptic gastroduodenal diseases].

Proteolytic activity of uropepsinogen as a marker of gastroduodenal diseases of peptic character was studied in 92 children aged 7-9 years and it was analyzed in parallel with specific features of their mothers' pregnancy. The findings obtained and literature data show that the genotypical features of the fetus can play a certain role in genesis of the specific course of the mothers' pregnancy and manifest themselves phenotypically via the elevated level of uropepsinogen proteolytic activity in the children at the age of 7-9 years with possible formation of gastroduodenal diseases in them.

[Impact of specific antituberculosis therapy on gastrointestinal tract in children].

Forty eight children aged 3 to 14 years treated at hospital for various tuberculous abnormalities were examined. The findings suggest that the use of antituberculosis agents in children with normal acid and pepsin production failed to have a noticeable effect on the gastrointestinal tract. Moreover, the 6-month use of highly and moderately effective antituberculosis agents produced no effect on the aggressive properties of gastric juice.

[Genetic aspects of hyperpepsinogenetic duodenal ulcer].

The authors provide the data of examination of 93 children aged 2 to 15 years and their 67 parents with regard to familial predisposition to the hyperpepsinogenemic form of duodenal ulcer. It has been established that the content of uropepsinogen was appreciably heightened only in those children in whom one of the parents of the opposite sex as regards the child's sex had hyperpepsinogenemic duodenal ulcer. The problems of hyperpepsinogenuria inheritance couple with sex are discussed.

[Clinico-genetic problems of peptic ulcer in children].

Based on the results of 11200 endoscopies of the stomach and duodenum, the incidence of peptic ulcer in children was established with regard to the sex and site of ulcer. The authors view peptic ulcer as a heterogeneous disease in terms of the genealogical data and differences in proteolytic activity of gastric proteases in biological media.