Publications by authors named "T Itokazu"
Article Synopsis
- Repulsive Guidance Molecule A (RGMa) is important for guiding nerve connections and has shown various functions in brain diseases like spinal cord injury and Parkinson's disease.
- In this study, RGMa's role was investigated in a mouse model of vascular dementia (VaD), where it was found to be overexpressed in the hippocampus, leading to cognitive decline.
- Treatment with an anti-RGMa neutralizing antibody not only improved cognitive function but also reversed the negative effects of RGMa on neurogenesis and cholinergic innervation, indicating a potential new treatment for VaD.
Article Synopsis
- Subarachnoid hemorrhage (SAH) can lead to cerebral ischemia, and recent research suggests that microvasospasm, influenced by perivascular inflammation, plays a role in this condition.
- A mouse model with intravital 2-photon imaging was used to study vascular and perivascular changes following SAH, revealing that neutrophils and neutrophil extracellular traps (NETs) contribute to the development of microvasospasms.
- The findings indicate that targeting perivascular NETs could be a potential new treatment approach for mitigating microvasospasm-related issues in SAH.
Midbrain dopamine neurons impact neural processing in the prefrontal cortex (PFC) through mesocortical projections. However, the signals conveyed by dopamine projections to the PFC remain unclear, particularly at the single-axon level. Here, we investigated dopaminergic axonal activity in the medial PFC (mPFC) during reward and aversive processing.
View Article and Find Full Text PDFSignificance: The initiation of goal-directed actions is a complex process involving the medial prefrontal cortex and dopaminergic inputs through the mesocortical pathway. However, it is unclear what information the mesocortical pathway conveys and how it impacts action initiation. In this study, we unveiled the indispensable role of mesocortical axon terminals in encoding the execution of movements in self-initiated actions.
View Article and Find Full Text PDFParkinson's disease (PD) is characterized by the pathological accumulation of α-synuclein (α-syn) and loss of dopaminergic neurons in the substantia nigra. Aging is a significant risk factor for PD. The accumulation of senescent glial cells in the aged brain contributes to PD progression by inducing chronic neuroinflammatory processes.
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