Publications by authors named "T Ispoglou"
Background: Acute sarcopenia is sarcopenia lasting less than 6 months, typically following acute illness or injury. It may impact patient recovery and quality of life, advancing to chronic sarcopenia. However, its development and assessment remain poorly understood, particularly during hospitalisation.
View Article and Find Full Text PDFCancer cachexia (CC) syndrome, a feature of cancer-associated muscle wasting, is particularly pronounced in older patients, and is characterised by decreased energy intake and upregulated skeletal muscle catabolic pathways. To address CC, appetite stimulants, anabolic drugs, cytokine mediators, essential amino acid supplementation, nutritional counselling, cognitive behavioural therapy, and enteral nutrition have been utilised. However, pharmacological treatments that have also shown promising results, such as megestrol acetate, anamorelin, thalidomide, and delta-9-tetrahydrocannabinol, have been associated with gastrointestinal and cardiovascular complications.
View Article and Find Full Text PDFArticle Synopsis
- The review discusses how cardiovascular disease (CVD) and metabolic diseases (MDs) are linked to sarcopenia and highlights the importance of non-drug therapies like combined training in managing these issues, especially in individuals with type II diabetes.
- It emphasizes the critical role nutrition plays in treating sarcopenia, suggesting methods like increasing protein intake, using plant-based sources, and ensuring nutrients like omega-3 fatty acids and vitamin D are adequate.
- Lastly, the review advocates for multidisciplinary strategies that incorporate behavioral science to enhance the effectiveness and sustainability of sarcopenia treatments while calling for more rigorous research to refine these interventions for older adults.
Key Clinical Message: In MS patients, especially those frail or malnourished, combining home-based exercise twice weekly with essential amino acids and vitamin D may improve body composition, strength, and physical performance, enabling long-term functional improvements.
Abstract: Multiple sclerosis (MS) is associated with reduced bone and muscle strength and function. We aimed to investigate the effectiveness of a 24-week intervention in a 57-year-old frail female with MS.
Low handgrip strength, a hallmark measure of whole-body strength, has been linked with greater odds of cognitive decline and dementia; however, conflicting findings, which could be due to population characteristics and choice of tools, such for the assessment of handgrip strength and cognitive function domains, also exist. Therefore, we examined the relationship of handgrip strength with a comprehensive list of tests to assess domains of cognitive function using a representative sample of US older men and women without neurodegenerative disorders such as dementia. We analyzed cross-sectional data from the US National Health and Nutrition Examination Survey (NHANES) between 2011 and 2014, with a study cohort of 777 older adults (380 men and 397 women) above 60 years of age.
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