Publications by authors named "T Isbir"
Background/aim: Ovarian cancer, despite being the fifth most common gynecological malignancy, has the highest mortality rate. Recent clinical studies have explored the potential of natural products, like curcumin (CUR), to enhance conventional chemotherapy by targeting multiple cellular pathways. This study aimed to evaluate the effects of CUR and its analog, demethoxycurcumin (DMC), on human ovarian cancer and cisplatin-resistant ovarian cancer cell proliferation and apoptosis.
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- Ovarian cancer (OC) has a high mortality rate, particularly in advanced stages, so understanding genetic factors is important for prevention and treatment; this study focuses on the roles of two DNA repair-related genes, XPC and DDB2, in OC susceptibility.
- The study examined genetic variations in XPC rs2228001 and DDB2 rs830083 among 103 OC patients and 104 control subjects from Turkey, utilizing a PCR genotyping method.
- Results indicated that certain genotypes of XPC and DDB2 are linked to either reduced or increased risk of developing OC, highlighting the significance of DNA repair systems in the disease and suggesting the need for more extensive research
Background/aim: MicroRNAs (miRNAs) have been identified as key regulators in various cancer types, including brain tumors. This study aimed to investigate the differential expression of miRNA-17 in glial tumors, cerebral metastases, and normal glial tissues.
Materials And Methods: A total of 42 patients were included in this cross-sectional study.
Investigation of Mirna-223-3p Expression in Non-small Cell Lung Cancers.
Anticancer Res
February 2024
Background/aim: Lung cancer remains a principal cause of cancer-related mortality worldwide. Non-small cell lung cancer (NSCLC), representing a significant 80-85% of lung cancer diagnoses, often presents at an advanced stage, with many patients demonstrating local growth or metastasis at the time of detection. Consequently, there exists a pressing need for augmented research into the molecular and genetic underpinnings of this malignancy to facilitate the development of innovative therapeutic and preventative strategies.
View Article and Find Full Text PDFOvarian cancer (OC) ranks seventh among malignant tumors worldwide. As one of the most common gynecological malignancies, ovarian cancer has the second-highest mortality rate, after cervical and uterine cancer. Next-Generation Sequencing (NGS) technology has enhanced multi-gene panel analysis and its clinical utility for identifying cancer-causing gene mutations.
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