Publications by authors named "T Isaacs"
Background: Monitoring is a crucial part of trial conduct and ensures that participants' data is fairly represented, and future healthcare information is enhanced. This project aims to improve trial monitoring by creating a trial monitoring plan (TMP) template with input from individuals experienced in monitoring clinical trials.
Methods: A review of monitoring plans received from UK Clinical Research Collaboration (UKCRC) registered clinical trials units (CTU)s created the basis for a preliminary TMP template and a Delphi survey.
Article Synopsis
- The review examines the effectiveness of telephone and video consultations in telepharmacy for adult outpatients since June 2016, specifically noting the increased use during the COVID-19 pandemic.
- Conducted as a systematic review, the study analyzed data from 2129 articles and included 103 eligible studies, revealing that most telepharmacy services relied on telephone consultations (87%) compared to video (13%).
- Results indicated that patients found telepharmacy consultations delivered comparable or superior care to traditional in-person services, with success factors including access to training, technical support, and digital literacy.
Article Synopsis
- * A study at Toronto's Hospital for Sick Children assessed 17 children with a history of childhood ICH, discovering that their average Full Scale IQ (FSIQ) is in the clinically average range but tends to be lower overall.
- * About 50-60% of participants showed deficits in areas like verbal learning, verbal memory, and processing speed, indicating a need for thorough clinical evaluations of neuropsychological abilities in these youth.
Background: It is important to design clinical trials to include all those who may benefit from the intervention being tested. Several frameworks have been developed to help researchers think about the barriers to inclusion of particular under-served groups when designing a trial, but there is a lack of practical guidance on how to implement these frameworks. This paper describes the ACCESS project, the findings from each phase of the project and the guidance we developed (STEP UP) on how to design more inclusive trials.
View Article and Find Full Text PDF