Publications by authors named "T Isaac Joseph"
Objectives: To compare the manual dexterity and composure under pressure of people in different hospital staff roles using a buzz wire game.
Design: Prospective, observational, comparative study (Tremor study).
Setting: Leeds Teaching Hospitals NHS Trust, Leeds, UK, during a three week period in 2024.
Approach advancements for engineering novel peptide analogs of existing lantibiotics: where are we today?
Expert Opin Drug Discov
December 2024
Introduction: The emergence of antibiotic resistance among the clinically important bacterial pathogens has increased healthcare costs and reduced patient safety and quality of life. Lantibiotics is a large class of ribosomally synthesized, and posttranslationally modified peptides have been the primary focus of numerous research aimed at discovering compounds for treating bacterial infections.
Areas Covered: The article explains the most up to date hierarchy of methods followed in the field for high throughput screening of lantibiotics/analogs with improved therapeutic properties.
Impact of endometriosis on oocyte quality in women undergoing assisted reproduction.
Minerva Obstet Gynecol
December 2024
Article Synopsis
- Endometriosis is a chronic condition that can result in infertility for women of reproductive age and affects assisted reproductive technology (ART) outcomes by impacting oocyte and embryo quality, numbers, and endometrial receptivity.
- There has been debate on whether the main issue in pregnancy outcomes for women with endometriosis arises from the quality of oocytes or the condition of the endometrium.
- Recent studies indicate that instead of oocyte quality, reduced oocyte yield may be a key factor diminishing ART success rates in women with endometriosis.
Article Synopsis
- The study aimed to compare the effectiveness of a combination treatment of Letrozole and Clomiphene Citrate versus Letrozole alone for inducing ovulation in infertile women with PCOS.
- Conducted as a randomized controlled trial from September 2020 to March 2023, it involved 120 women who were randomly assigned to either treatment group over three menstrual cycles.
- Results showed no significant differences in ovulation rates, clinical pregnancy rates, or live birth rates between the two groups, indicating that the combination treatment did not provide additional benefits over Letrozole alone.