Bone marrow transplantation for chronic granulocytic leukemia.

Thirty-seven patients with chronic granulocytic leukemia have been treated with supralethal chemoradiotherapy followed by transplantation of bone marrow from HLA-identical donors. All patients showed engraftment, and the Philadelphia chromosome (PH1) disappeared in each case. Four patients had syngeneic grafts before blast crisis and are still alive; 2 are in remission not maintained by therapy, and 2 others are receiving chemotherapy after having relapsed in the chronic phase.

[Specific antibodies against lymphocytes and monocytes in multiple-transfused uremic patients].

Kidney patients waiting for transplant usually undergo deliberate transfusion without clinical need in order to improve the outcome of the transplantation. Besides the beneficial transfusion effect on graft survival antibodies against the Major Histocompatibility Complex (MHC) can be detected after blood transfusions. Preliminary studies have shown antibodies against surface determinants of endothelial cells and monocytes too.