Publications by authors named "T Inazumi"
While the skin is a common target organ for sarcoidosis, cutaneous granulomatous vasculitis is rare among patients with sarcoidosis. Due to the lack of detailed studies on cutaneous sarcoid vasculitis, both dermatologists and pathologists remain unfamiliar with this rare but important vasculitic disorder. We clinicopathologically evaluated eight cases with biopsy-proven cutaneous vasculitis and cutaneous sarcoidosis and analyzed morphologic changes in the process of vasculitis for both small vessels and muscular vessels in detail.
View Article and Find Full Text PDFKey Points: Omega-3 polyunsaturated fatty acids prevent AKI to CKD transition and renal fibrosis. Eicosapentaenoic acid metabolites 18-hydroxyeicosapentaenoic acid, 17,18-epoxyeicosatetraenoic acid, and 17,18-dihydroxyeicosatetraenoic acid have antifibrotic effects.
Background: AKI is an established risk factor for developing CKD.
Article Synopsis
- Researchers examined the roles of prostaglandins (PGs) in the uterus by studying various PG receptor expressions during pregnancy, finding key receptors in luminal and stromal cells.
- The expression of the DP receptor was notably induced in stromal cells after embryo attachment, aligning with COX-2 expression, while both PGD and PGE were synthesized in significant amounts during implantation.
- The study revealed that the DP and EP4 receptors play crucial roles in the process of decidualization, with pharmacological interventions suggesting their coordinated functions despite the lack of impact from DP/EP2 double deficiency.
Article Synopsis
- The text discusses a previously underestimated pathogen that is part of normal skin flora but is now recognized for causing severe infections, especially in immunocompromised patients.
- Identifying this pathogen at the species level poses challenges in clinical microbiology, which limits understanding of its role in infectious diseases.
- A rare case study is presented involving a patient with severe neutropenia who developed multiple subcutaneous abscesses, with the pathogen identified through genotyping, emphasizing its significance in severe skin infections.
Article Synopsis
- Extramammary Paget disease (EMPD) is a skin cancer primarily found in the genital and underarm areas of older adults, with limited studies on its genetics, especially in familial cases.* -
- This report presents the first known familial cases of EMPD involving three siblings, who all showed a specific genetic variant in the MET gene linked to the disease.* -
- Further research is needed to better understand the impact of MET gene variants on the development of EMPD, particularly in families with multiple affected members.*