Publications by authors named "T Imatoh"
Background: We aimed to evaluate the validity of self-administered questionnaire surveys and face-to-face interview surveys for the detection of Helicobacter pylori eradication therapy.
Methods: Participants were a cohort, aged 40-74 years, living in three different locations of Japan, who took part in the baseline survey (2011-2012) of the Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT). Five years after the baseline survey, a questionnaire and interview survey were independently conducted to determine the history of Helicobacter pylori eradication treatment over the 5-year period.
Article Synopsis
- Bortezomib (BTZ) is a chemotherapy drug for multiple myeloma but can cause severe lung-related side effects that are not fully understood.
- This study aimed to explore how BTZ affects blood vessel permeability and the expression of proteins that maintain cell connections in human lung cell models.
- The findings showed that BTZ increases the permeability of lung endothelial cells while decreasing key proteins related to cell junctions, which suggests that it contributes to vascular complications in lung tissue.
Article Synopsis
- A study was conducted to explore how azole antifungals affect the side effects of bortezomib, a cancer treatment, using the Japanese adverse drug event report database.
- Researchers analyzed 19,567 reports and found notable increases in adverse reactions like peripheral neuropathy when azoles were used with bortezomib.
- Specifically, the interaction was stronger with itraconazole compared to fluconazole, suggesting that azoles may intensify bortezomib’s side effects due to their pharmacological properties.
Article Synopsis
- The study aimed to determine how common a family history of cancer is among participants in the Japanese National Center Cohort Collaborative for Advancing Population Health.
- The results showed that the prevalence of family history of cancer increases with age, with 10.51% in younger participants (15-39 years) and 47.11% in older adults (70 years and above).
- Gastric cancer was the most frequently reported among family members at 11.97%, with women having a higher prevalence (34.32%) than men (28.75%), indicating a need for focused cancer screening services.
Background: Evidence of the association between chronic low-grade inflammation, as reflected by C-reactive protein (CRP) measurements, and cancer risk is equivocal. Specifically, few studies have examined this in uncommon cancers and Asian populations.
Methods: We utilised a case-cohort design consisting of multi-types of cancer (N = 3608), and a random subcohort (N = 4432) in a Japanese large population-based study, with a median follow-up time of 15.