Publications by authors named "T Imasawa"

Background: Kidney complications associated with anticancer drug therapy have greatly increased recently. We aimed to investigate the real-world clinical outcomes of anticancer drug therapy-associated renal complications in Japan using the national kidney biopsy database, Japan Renal Biopsy Registry (J-RBR).

Methods: From 2018 to 2021, 449 cases from 49 facilities identified as 'drug-induced' histopathology in the J-RBR were screened, of which a total of 135 were confirmed as anticancer drug-related cases and included in the analysis.

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Mitochondrial nephropathy is a genetic renal disease characterized by oxidative phosphorylation abnormalities in the mitochondrial respiratory chain in kidney cells, caused by pathogenic gene variants located on mitochondrial or nuclear DNA. Recent advancements in genetic diagnostic techniques and their widespread adoption have led to the identification of various genes associated with mitochondrial nephropathy. This review investigates the causative genes and clinicopathological features of mitochondrial nephropathy, including the various phenotypes and associated complications, and suggests potential pathogenic mechanisms.

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Article Synopsis
  • The study evaluated the health-related quality of life (QOL) in 10-year survivors of chronic kidney disease (CKD) in Japan, highlighting the impact of CKD and cardiovascular disease (CVD) on their well-being.
  • Data was collected from 1,473 participants using the EQ-5D-5L instrument, with a response rate of 38.2%, revealing a mean QOL score of 0.893 and demonstrating variations based on treatment status and CVD presence.
  • Significant factors influencing QOL included baseline age, blood pressure, and a history of hyperuricemia, indicating that CKD complications substantially impact long-term survivors' quality of life.
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