Publications by authors named "T Imaeda"
Article Synopsis
- A nationwide study in Japan analyzed the relationship between intensive care unit (ICU) case volume and outcomes for sepsis patients using data from 2010 to 2017.
- The study found that patients in higher-volume ICUs had significantly lower in-hospital mortality rates compared to those in lower-volume ICUs, indicating that more experience in treating sepsis correlates with better patient outcomes.
- However, higher-volume ICUs also incurred higher daily medical costs, suggesting a trade-off between cost and quality of care, especially for patients requiring advanced therapies like mechanical ventilation.
Few population-based studies including younger adults have examined the potential of olfactory function tests to capture the degree of atrophy in memory-associated brain regions, which cannot be adequately explained by cognitive function tests screening for cognitive impairment. This population-based study investigated associations between high-resolution olfactory test data with few odours and grey matter volumes (GMVs) of the left and right hippocampi, amygdala, parahippocampi, and olfactory cortex, while accounting for differences in cognitive decline, in 1444 participants (aged 31-91 years). Regression analyses included intracranial volume (ICV)-normalised GMVs of eight memory-related regions as objective variables and age, sex, education duration, smoking history, olfaction test score, and the Montreal Cognitive Assessment-Japanese version (MoCA-J) score as explanatory variables.
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- - A study analyzed over 73 million hospitalized patients in Japan from 2010 to 2019 to explore the prevalence of community-acquired infections (CAI) and nosocomial infections (NI), finding increases in both types of infections, particularly among those aged 85 and older.
- - The research indicated that 9.7% of patients had CAI and 4.7% had NI, with NI having a higher in-hospital mortality rate (14.5% vs. 8.3%) and resulting in longer hospital stays and greater medical costs.
- - Despite the overall decline in mortality rates for both infections over the years, the data highlights the significant impact of NI on older patients, undersc
Background: Following marketing authorization in Japan, for almost all new drugs or new indications, postmarketing studies (PMS) are a regulatory requirement. These PMS focus on accrual of a defined number of cases with data being collected for a predetermined period after approval to confirm efficacy/effectiveness, safety, and quality in the Japanese population. In contrast to other regions where PMS are only required to address a specific scientific uncertainty, in Japan, PMS are often required regardless of any specific scientific uncertainty, and therefore, their scientific value is unclear.
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- The study aimed to analyze the initial antimicrobial treatment options for patients with community-onset sepsis in Japan, using a large dataset from a medical reimbursement system.
- Over 1.1 million patients were examined, revealing that third-generation cephalosporins and carbapenem were the most commonly prescribed antimicrobials, with only a small percentage receiving treatment for methicillin-resistant infections.
- The findings indicated that while many patients received antipseudomonal agents, combination therapies for drug-resistant bacteria were infrequently used, suggesting a potential gap in effective treatment strategies.