Publications by authors named "T Ikeno"
Article Synopsis
- Twisted intramolecular charge transfer (TICT) occurs when certain fluorescent dyes, upon being excited by light, undergo charge transfer and rotation that typically leads to non-fluorescence.
- Researchers found that modifying the size of substituents on rhodamine derivatives can adjust the strength of TICT and the resulting intramolecular steric repulsion.
- They developed a fluorescence probe that leverages this concept to detect nitroreductase (NTR) activity, which initially shows little fluorescence but dramatically increases when the NTR enzyme reacts with the probe, confirming that the intended chemical reactions occur.
Article Synopsis
- * A randomized trial involved 901 patients undergoing endoscopies, where 3G-NBI showed a higher detection rate for GNs (7.3%) compared to TXI (5.0%) and WLI (5.6%).
- * The findings suggest that 3G-NBI is superior in detecting GNs, leading to better outcomes, thereby highlighting its potential in clinical practices for early diagnosis.
Background And Aims: Endoscopic resection is a minimally invasive treatment for superficial esophageal squamous cell carcinoma (SESCC). Post-endoscopic resection scars complicate en-bloc resection, even with advanced techniques, such as endoscopic submucosal dissection. The cryoballoon ablation system (CBAS) effectively manages Barrett's esophagus but has limited evidence in SESCC treatment, particularly on post-endoscopic resection scars.
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- The study focuses on long-term outcomes for non-small cell lung cancer (NSCLC) patients, particularly those who survive 5 years post-surgery, as some may still experience recurrences after this milestone.
- Researchers analyzed data from 2482 NSCLC patients who underwent complete resection, finding that 9.3% of the 5-year survivors experienced recurrence after this point.
- Key factors linked to a higher risk of death included being 75 years or older, having lymph node metastasis, and experiencing pleural invasion, indicating the need for extended follow-up for certain patients.
Background/aim: This study aimed to investigate the efficacy and safety of gemcitabine (GEM) plus nab-paclitaxel (nab-PTX), termed GnP, which is limited, in patients with advanced pancreatic cancer (PC) who show good tolerance to GEM monotherapy prior to being refractory to it.
Patients And Methods: We retrospectively analyzed the data of patients with locally advanced or metastatic PC who received GEM followed by GnP between December 2014 and March 2019, regardless of the treatment line.
Results: A total of 14 patients who received GnP after becoming refractory to GEM were included in this study.