Publications by authors named "T Ikenaga"
Article Synopsis
- The study assessed the effects of prophylactic neck dissection and additional therapy on patients undergoing transoral surgery for hypopharyngeal cancer from 2015 to 2021.
- Out of 221 patients, a high 3-year local recurrence-free survival rate of 89.1% was observed, but positive margins led to higher rates of regional recurrence and distant metastasis, though local recurrence did not affect overall survival.
- The conclusion suggests that monitoring for recurrences is important and that prophylactic neck dissection might not be essential for all patients with positive margins.
Platyhelminthes are a phylum of simple bilaterian invertebrates with prototypic body systems. Compared with non-bilaterians such as cnidarians, the bilaterians are likely to exhibit integrated free-moving behaviors, which require a concentrated nervous system "brain" rather than the distributed nervous system of radiatans. Marine flatworms have an early cephalized 'central' nervous system compared not only with non-bilaterians but also with parasitic flatworms or freshwater planarians.
View Article and Find Full Text PDFObjective: Transoral surgery is a minimally invasive treatment but may cause severe dysphagia at a lower rate than chemoradiotherapy.
Methods: We compared clinical information, surgical complications, and swallowing function in patients who underwent transoral nonrobotic surgery for laryngo-pharyngeal squamous cell carcinoma between 2015 and 2021 in a multicenter retrospective study.
Results: Six hundred and forty patients were included.
Scope: This study examines whether coingestion of γ-aminobutyric acid (GABA) and malic acid (MA) before meals enhances glucagon-like peptide-1 (GLP-1) secretion, and which affects subsequent insulin and glycemic responses in humans.
Methods And Results: Initially, a murine enteroendocrine STC-1 cell line is used to verify coadministration of GABA and MA synergistically induces GLP-1 secretion. Next, 22 healthy adults are given water (50 mL) containing 400 mg GABA and 400 mg MA (Test), or only 400 mg citric acid (CA) (Placebo) 20 min before meal tolerance test (MTT).
Background: Hypopharyngeal carcinoma is likely to spread to the lymph nodes, but there is no established strategy for management in transoral surgery.
Methods: We compared oncologic and functional outcomes in a retrospective multicenter study of patients who underwent transoral surgery for hypopharyngeal carcinoma between 2015 and 2021.
Results: Two-hundred and thirty-two patients were included.