Publications by authors named "T Ijichi"
Baseline cardiac functions are known to be potent predictors of cardiovascular events in the natural history of transthyretin amyloid cardiomyopathy (ATTR-CM). However, previous studies have not shown functional and morphological changes in the heart during tafamidis administration. This study aimed to evaluate the effect of tafamidis on cardiac function by measuring right ventricular strain in patients with ATTR-CM.
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- * Edible bird's nest (EBN), which is swiftlet saliva consumed for health benefits, shows anti-avian viral properties, particularly by inhibiting the receptor-binding hemagglutinin (HA) activity after pancreatin treatment.
- * EBN, rich in specific glycan structures, effectively enhances the action of antiviral drugs oseltamivir and zanamivir, suggesting its potential as a food-derived solution to combat avian viruses and reduce the risk of pandemics.
Background: Guideline-directed medical therapy has become an important component of heart failure (HF) therapy, with sacubitril/valsartan as one of the recommended drugs; however, the real-world prognostic implications of sacubitril/valsartan uptitration are unclear.
Methods And Results: Patients with HF newly initiated on sacubitril/valsartan were registered in a retrospective multicenter study (REVIEW-HF). In all, 995 patients were divided into 3 groups according to the maximum dose achieved: high dose, sacubitril/valsartan 400 mg; intermediate dose, sacubitril/valsartan 200-<400 mg; and low dose, sacubitril/valsartan <200 mg.
Background: Patients with heart failure exhibiting low systolic blood pressure (SBP) have a poor prognosis. Sacubitril/valsartan reduces cardiovascular events; however, its use in patients with low SBP has not been fully examined. Therefore, in this study, we aimed to investigate the association between baseline SBP and adverse events (AEs) in patients starting sacubitril/valsartan therapy using data from a real-world registry in Japan.
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- Postoperative pancreatic fistula (POPF) is a common complication after distal pancreatectomy (DP), prompting a study (WRAP study) to assess new prevention strategies during minimally invasive DP (MIDP).
- The trial involves 172 patients at 14 centers in Japan, randomly assigning them to either a control group or an intervention group that uses polyglycolic acid (PGA) mesh and fibrin glue to reinforce the pancreatic stump.
- The primary goal is to evaluate whether this reinforcement can reduce the occurrence of clinically relevant POPF, potentially establishing a new best practice in MIDP surgery.