Publications by authors named "T Igaki"
Selective elimination of cancer cells without causing deleterious effects on normal cells is an ideal anti-cancer strategy. Here, using Drosophila cancer model, we performed an in vivo RNAi screen for anti-cancer targets that selectively eliminate tumors without affecting normal tissue growth. In Drosophila imaginal epithelium, clones of cells expressing oncogenic Ras with simultaneous mutations in the cell polarity gene scribble (Ras/scrib) develop into malignant tumors.
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- This study looked at patients with Stage II colorectal cancer to understand why some people get better and some have a relapse.
- They found that certain genetic changes and features in tumors, like how they grow, can affect a person's chances of staying cancer-free after treatment.
- By studying these factors, doctors might be able to choose better treatments for patients and help them avoid coming back to the hospital for more problems.
Multicellular communities have an intrinsic mechanism that optimizes their structure and function via cell-cell communication. One of the driving forces for such self-organization of the multicellular system is cell competition, the elimination of viable unfit or deleterious cells via cell-cell interaction. Studies in Drosophila and mammals have identified multiple mechanisms of cell competition caused by different types of mutations or cellular changes.
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- Shared decision making (SDM) is essential in discussing treatment options for pregnant women diagnosed with breast cancer, as it involves joint decision-making between the patient and healthcare providers.
- A pregnant woman in her 30s with Stage I breast cancer opted for conservative surgery instead of a total mastectomy after thorough risk discussions, leading to a partial mastectomy and lymph node sampling.
- Although the recommended radiotherapy was delayed to allow for breastfeeding, SDM was important in navigating her treatment choices, highlighting the need for a balance between patient preferences and optimal health practices in pregnancy-related breast cancer cases.
The ribosome is a molecular machine essential for protein synthesis, which is composed of approximately 80 different ribosomal proteins (Rps). Studies in yeast and cell culture systems have revealed that the intracellular level of Rps is finely regulated by negative feedback mechanisms or ubiquitin-proteasome system, which prevents over- or under-abundance of Rps in the cell. However, in vivo evidence for the homeostatic regulation of intracellular Rp levels has been poor.
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