Publications by authors named "T Idziorek"
Background: The Ets-1 transcription factor plays a primordial role in regulating the expression of numerous genes implicated in cancer progression. In a previous study, we revealed that poly(ADP-ribose) polymerase-1 (PARP-1) inhibition by PJ-34 results in Ets-1 level increase in cells, which is related with cell death of Ets-1-expressing cancer cells.
Aims: The mechanism of the antitumor effect of PARP-1 inhibition was investigated in the Ets-1-expressing MDA-MB-231 breast cancer cells.
Article Synopsis
- Tumor dormancy is when cancer cells can hide and become resistant to treatments, making it hard to fully get rid of cancer.
- The study looked at how these dormant cancer cells work using special models of leukemia and melanoma, using lots of different scientific techniques to understand their behavior and find new ways to treat them.
- Researchers found unique gene mutations and changes in proteins in dormant cells, suggesting how they survive and resist therapies, which could help develop better treatments for patients.
Article Synopsis
- * Researchers studied 67 samples from 48 patients to identify genetic changes linked to high-risk disease stages and worse survival rates, finding specific genomic alterations like gain7q and del6q16.3 associated with poor prognosis.
- * The study revealed different evolutionary pathways of MF, as well as potential biomarkers for identifying patients at higher risk of disease progression, emphasizing the importance of genomic analysis in managing MF.
Older age is one of the strongest risk factors for severe COVID-19. In this study, we determined whether age-associated cellular senescence contributes to the severity of experimental COVID-19. Aged golden hamsters accumulate senescent cells in the lungs, and the senolytic drug ABT-263, a BCL-2 inhibitor, depletes these cells at baseline and during SARS-CoV-2 infection.
View Article and Find Full Text PDFAcute myeloid leukemia (AML) is characterized by genetic aberrations in hematopoietic precursors of the myeloid lineage which lead to their defective maturation/function. While intensive chemotherapy protocols result in complete remission in 50 % to 80 % of AML patients, relapse occurs in the majority of cases. While calcium signalling is a well-known contributor to cancer hallmarks, few AML related studies have focused on relevant calcium targets.
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