Mesoscale heterogeneity is a critical determinant for spiral pattern formation in developing social amoeba.

Heterogeneity is a critical determinant for multicellular pattern formation. Although the importance of microscale and macroscale heterogeneity at the single-cell and whole-system levels, respectively, has been well accepted, the presence and functions of mesoscale heterogeneity, such as cell clusters with distinct properties, have been poorly recognized. We investigated the biological importance of mesoscale heterogeneity in signal-relaying abilities (excitability) in the self-organization of spiral waves of intercellular communications by studying the self-organized pattern formation in a population of Dictyostelium discoideum cells, a classical signal-relaying system model.

Dihydrolevoglucosenone (CyreneTM) as a Bio-derived Liquid Organic Hydrogen Carrier.

Organic hydrides can store hydrogen via chemical bonding under ambient conditions, enabling the safe storage and transportation of hydrogen gas using the same infrastructure for gasoline. However, in previous research, most organic hydrides have been produced from petroleum, and therefore replacing them with earth-abundant or renewable compounds is essential to ensure sustainability. This study demonstrates dihydrolevoglucosenone (CyreneTM), which is a biodegradable liquid ketone that is produced directly from biomass without pretreatments on an industrial scale, as a new renewable organic hydride.

Clinical impact of multidisciplinary team management on postoperative short-term outcomes in colorectral cancer surgery.

The multidisciplinary team (MDT) approach has become the standard for perioperative patient care. At our institution, a multidisciplinary perioperative care team called "Surgical, Nutrition and Rehabilitation Integrated Services for Excellence Team (SUNRISE)" was established for all patients with gastrointestinal cancer undergoing surgery. This study aimed to elucidate the significance of SUNRISE as a perioperative MDT by comparing short-term postoperative outcomes before and after the introduction of SUNRISE in patients with colorectal cancer.

Clinical Impact of Weight Loss During Hospitalization on Prognosis After Pancreatic Surgery.

Purpose This study aimed to elucidate the relationship between early-stage weight loss (WL) during hospitalization after pancreatic surgery and prognosis and investigate risk factors affecting WL. Methods We included 68 patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) who underwent radical surgery. The %WL value was calculated based on the percentage of body weight at discharge compared with the body weight at admission.