Publications by authors named "T Ichiki"
Coarse-grained molecular dynamics (CG-MD) simulations and subsequent persistent homology (PH) analysis were performed to correlate the structure and stress-strain behavior of polymer films. During uniaxial tensile MD simulations, the first principal component of the persistence diagram obtained by principal component analysis (PCA) was in good agreement with the stress-strain curve. This indicates that PH + PCA can identify critical ring structures relevant to the dynamic changes in MD simulations without requiring any prior knowledge.
View Article and Find Full Text PDFArticle Synopsis
- - Atopic dermatitis (AD) involves chronic inflammation and a weakened skin barrier, worsened by factors like scratching, and this study looks into how extracellular ATP affects AD.
- - The research found that ATP reduces filaggrin, a protein vital for skin barrier strength, and heightens inflammation by stimulating immune cell activity when released due to IL-4 and mechanical triggers.
- - Clodronate, which inhibits ATP release, shows promise in restoring filaggrin levels and reducing inflammation in a mouse model of AD, suggesting that targeting ATP could be a new way to treat this condition.
Introduction: Cutaneous squamous cell carcinoma (cSCC) is a common form of skin cancer. Less accessibility to the cSCC cell lines has limited analyses of this disease. Thus, we here aimed to establish novel cSCC cell lines from patient's cSCC lesions.
View Article and Find Full Text PDFArticle Synopsis
- PRAME, originally found in malignant melanoma, has recently been identified in some cases of fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP), while conventional dermatofibrosarcoma protuberans (C-DFSP) tested negative.
- A study examined 21 cases of FS-DFSP alongside matched controls of C-DFSP using immunohistochemistry, revealing a significantly higher presence of PRAME in FS-DFSP (p = 0.0137) and a lower presence of CD34 (p < 0.001).
- The combination of PRAME and CD34 analyses provided a diagnostic sensitivity of 86% and specificity of 90